The G4 Resolvase DHX36 Possesses a Prognosis Significance and Exerts Tumour Suppressing Function Through Multiple Causal Regulations in Non-Small Cell Lung Cancer

Lung cancer is one of the most prevalent cancers in both men and women worldwide. The nucleic acid G4 structures have been implicated transcriptional programmes cancer-related genes some such as lung cancer. However, role dominant resolvase DHX36 progression remains unknown. In this study, by bioinformatic analysis public datasets (TCGA GEO), we find an independent prognosis indicator non-small-cell carcinoma (NSCLC) with subtype dependence. stable lentiviral knockdown results accelerated migration aggregation S-phase subpopulation cells. reduction level de-sensitises proliferation response cells to chemotherapeutic drugs paclitaxel cell helicase leads promoted tumour growth, demonstrated a 3D fluorescence spheroid model, stimulation colony formation shown single-cell cultivation. High throughput proteomic array indicates that functions through regulating multiple signalling pathways including activation protein activity, autophosphorylation, Fc-receptor pathway, peptide hormone stress-activated kinase cascade. A causal transcriptomic suggests significantly associated mRNA surveillance, RNA degradation, DNA replication Myc targets. Therefore, unveil presents clinical significance plays suppression cancer, propose potentially new concept for anti-cancer therapy based on helicase-specific targeting.